Caloric Restriction (CR)
Reduction in energy intake (typically 15-40%) without malnutrition, shown across model organisms to extend lifespan and healthspan, with active human research (CALERIE) demonstrating cardiometabolic and possibly aging biomarker benefit.
Also: CR, Dietary restriction
CR engages a coordinated response involving downregulated mTORC1/IGF-1 signaling, upregulated AMPK and sirtuins, increased autophagy, and elevated FGF21. CALERIE 2 showed sustained 12% restriction in non-obese humans reduced cardiometabolic risk and slowed epigenetic aging clocks. Intermittent fasting and time-restricted eating partially recapitulate CR signaling. MNHD Ch 51 frames CR as the conceptual prototype for dietary restriction biology.
How one textbook covers it
Modern Nutrition in Health and Disease, 12th ed. — Ch 51: Metabolic and Molecular Consequences of Dietary Restriction
CR engages a coordinated response involving downregulated mTORC1/IGF-1 signaling, upregulated AMPK and sirtuins, increased autophagy, and elevated FGF21. CALERIE 2 showed sustained 12% restriction in non-obese humans reduced cardiometabolic risk and slowed epigenetic aging clocks. Intermittent fasting and time-restricted eating partially recapitulate CR signaling. MNHD Ch 51 frames CR as the conceptual prototype for dietary restriction biology.
Related terms
AMPK, FGF21, Intermittent fasting, Sirtuins, mTORC1