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FADS Gene Cluster

Gene cluster (FADS1/FADS2/FADS3) encoding delta-5 and delta-6 desaturases that catalyze rate-limiting steps in long-chain PUFA biosynthesis from α-linolenic and linoleic acids.

Also: FADS1, FADS2, Fatty acid desaturase

Common FADS variants markedly affect circulating arachidonic acid, EPA, and DHA levels. The high-activity (D allele) haplotype is much more common in African and South Asian populations than European, with implications for omega-3 status on a vegetarian diet. FADS variants modify responses to dietary PUFA in lipid and inflammation outcomes and are central to precision nutrition arguments.

How one textbook covers it

  • Modern Nutrition in Health and Disease, 12th ed. — Ch 38: Nutritional Genomics

    Common FADS variants markedly affect circulating arachidonic acid, EPA, and DHA levels. The high-activity (D allele) haplotype is much more common in African and South Asian populations than European, with implications for omega-3 status on a vegetarian diet. FADS variants modify responses to dietary PUFA in lipid and inflammation outcomes and are central to precision nutrition arguments.

Related terms

ALA, DHA, EPA, Nutrigenomics