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Fibroblast Growth Factor 23 (FGF23)
Bone-derived phosphaturic hormone secreted by osteocytes that lowers serum phosphate by inhibiting renal NaPi-IIa/c reabsorption and suppressing renal CYP27B1, thereby reducing calcitriol synthesis.
Also: FGF23
FGF23 acts on the kidney via the FGFR1-Klotho coreceptor complex. It is induced by elevated phosphate and calcitriol and is a master counterregulator of vitamin D. In chronic kidney disease, FGF23 rises early as part of CKD-mineral bone disorder, suppressing calcitriol and contributing to secondary hyperparathyroidism. Elevated FGF23 is independently associated with cardiovascular mortality in CKD.
How one textbook covers it
Modern Nutrition in Health and Disease, 12th ed. — Ch 8: Phosphorus
FGF23 acts on the kidney via the FGFR1-Klotho coreceptor complex. It is induced by elevated phosphate and calcitriol and is a master counterregulator of vitamin D. In chronic kidney disease, FGF23 rises early as part of CKD-mineral bone disorder, suppressing calcitriol and contributing to secondary hyperparathyroidism. Elevated FGF23 is independently associated with cardiovascular mortality in CKD.
Related terms
Calcitriol, Klotho, PTH, Phosphate