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Glutathione Peroxidase (GPX)

Family of selenocysteine-containing antioxidant enzymes that reduce hydrogen peroxide and lipid hydroperoxides using reduced glutathione as electron donor, generating water and glutathione disulfide.

Also: GPX, Glutathione peroxidase

Eight GPX isoforms differ by tissue distribution and substrate preference. Erythrocyte GPX (GPX1) is used clinically as a selenium status biomarker. GPX4 reduces phospholipid hydroperoxides and is the central regulator of ferroptosis, a form of iron- and lipid peroxide-driven cell death increasingly implicated in disease.

How one textbook covers it

  • Modern Nutrition in Health and Disease, 12th ed. — Ch 15: Selenium

    Eight GPX isoforms differ by tissue distribution and substrate preference. Erythrocyte GPX (GPX1) is used clinically as a selenium status biomarker. GPX4 reduces phospholipid hydroperoxides and is the central regulator of ferroptosis, a form of iron- and lipid peroxide-driven cell death increasingly implicated in disease.

Related terms

Glutathione, Selenium, Selenoprotein