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Sepsis
Life-threatening organ dysfunction caused by a dysregulated host response to infection.
Diagnosed using SOFA score increases; septic shock requires persistent hypotension despite resuscitation plus lactate >2 mmol/L. Drives the metabolic stress response: hyperglycemia, accelerated proteolysis, lipid mobilization, and acute-phase protein synthesis. Early enteral nutrition within 24 to 48 hours of ICU admission is recommended unless hemodynamically unstable. Permissive underfeeding may be appropriate in the first week.
How one textbook covers it
Krause and Mahan's Food and the Nutrition Care Process, 16th ed. — Chapter 39
Diagnosed using SOFA score increases; septic shock requires persistent hypotension despite resuscitation plus lactate >2 mmol/L. Drives the metabolic stress response: hyperglycemia, accelerated proteolysis, lipid mobilization, and acute-phase protein synthesis. Early enteral nutrition within 24 to 48 hours of ICU admission is recommended unless hemodynamically unstable. Permissive underfeeding may be appropriate in the first week.
Related terms
Cytokine Storm, Multiple Organ Dysfunction Syndrome, SIRS