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Sirtuins

NAD+-dependent deacylase enzymes (SIRT1-SIRT7) that couple cellular NAD+ availability to deacetylation of histones, transcription factors, and metabolic enzymes, linking energy status to chromatin and metabolism.

Also: SIRT1-SIRT7

Sirtuins consume NAD+ to remove acetyl groups, releasing nicotinamide and O-acetyl-ADP-ribose. SIRT1 deacetylates PGC-1α, FOXO, and p53; SIRT3 regulates mitochondrial enzymes. Activation by caloric restriction, exercise, and NAD+ precursors (NR, NMN) has motivated geroscience interest. Resveratrol is a putative SIRT1 activator, though its in vivo specificity is contested.

How one textbook covers it

  • Modern Nutrition in Health and Disease, 12th ed. — Ch 24: Niacin

    Sirtuins consume NAD+ to remove acetyl groups, releasing nicotinamide and O-acetyl-ADP-ribose. SIRT1 deacetylates PGC-1α, FOXO, and p53; SIRT3 regulates mitochondrial enzymes. Activation by caloric restriction, exercise, and NAD+ precursors (NR, NMN) has motivated geroscience interest. Resveratrol is a putative SIRT1 activator, though its in vivo specificity is contested.

Related terms

AMPK, Caloric restriction, NAD, mTORC1